Hematoxylin and eosin stains of thyroid cancer cases harboring new or rare BRAF mutations. Left column, original magnification 40 x; right column, original magnification 400 x. A and B, FTC with a BRAF K601E mutation. Case has a single minimally invasive focus, marked by arrows. C and D, PTC with BRAF K601E mutation. The recurrence of the case involves subcutaneous tissue and skeletal muscle. Conventional PTC and squamous components are intermixed. E and F, FA harboring a deletion of BRAF codon 599. The tumor presents as a solitary encapsulated nodule and misses nuclear features of PTC.