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Table 1 The development of multiple primary tumors in patient (individual - index III: 4).

From: Novel germline MSH2 mutation in lynch syndrome patient surviving multiple cancers

Site of tumor

Age at diagnosis (years)

Histology

Stage (TNM)

Treatment

Ovary (right)

38

Mucinous cystadenocarcinoma

I (T1N0M0)

Radical hysterectomy+chemotherapy+

radiotherapy (1986)

Rectosigmoid

47

Mucinous adenocarcinoma

III (T3N1M0)

Resection of rectosigmoid part with "end-to-end anastomosis"+ chemotherapy

Breast (left)

51

Ductal adenocarcinoma

II (T2N0M0)

Mastectomy + radiotherapy (4 fields), tamoxifen (20 mg) 3 years

Ureter (left)

56

Transitional cell ureter carcinoma (G2)

II

(T2N0M0)

Resection of ureter + nephroectomy

Adenoma of parathyroid

57

  

Ultrasound biopsy

Ureteral metastasis in liver (S5-6)

60

Transitional cell ureter carcinoma (G2)

IV

Radiofrequency ablation

Colon (ascending)

61

Adenocarcinoma with partial mucinous differentiation (G2)

II (T3N0M0)

Right hemicolectomy

  1. All available pathology and medical reports of cancers occurring in this patient were reviewed.