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Table 2 Recommended colonic and extra-colonic surveillance in HNPCC

From: HNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review

Site

Screening

Colon

Annual full colonoscopy initiated between ages 20 and 25

Endometrium

Annual transvaginal ultrasound and Pelvic examination beginning at age 30; Endometrial aspiration for pathology assessment

Ovary

Transvaginal ovarian ultrasound and CA-125 analysis (serious limitations due to reduced sensitivity and specificity)

Stomach

Consider upper endoscopy in natives of Korea or Japan and/or in families with an excess of stomach cancer

Upper uro-epithelial tract

Urine samples for rbc and cytology in concert with ultrasound

Other sites

Consider in families with an excess of cancer of a particular extra-colonic site