From: HNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review
Bethesda Guidelines[30] |
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1. Subjects with cancer in families that fulfill Amsterdam Criteria. |
2. Subjects with two HNPCC-related cancers, including synchronous and metachronous CRCs or associated extracolonic cancers. |
3. Subjects with CRC and a first-degree relative with CRC and/or HNPCC-related extracolonic cancer and/or colorectal adenoma; one of the cancers diagnosed at age <45 years and the adenoma diagnosed at age <40 years. |
4. Subjects with CRC or endometrial cancer diagnosed at age <45 years. |
5. Subjects with right-sided CRC with an undifferentiated pattern (solid/cribiform) on histopathology diagnosed at age <45 years. |
6. Subjects with signet ring cell type CRC diagnosed at age <45 years. |
7. Subjects with adenomas diagnosed at age <40 years. |