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Table 3 Bethesda Guidelines [30]

From: HNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review

Bethesda Guidelines[30]

1. Subjects with cancer in families that fulfill Amsterdam Criteria.

2. Subjects with two HNPCC-related cancers, including synchronous and metachronous CRCs or associated extracolonic cancers.

3. Subjects with CRC and a first-degree relative with CRC and/or HNPCC-related extracolonic cancer and/or colorectal adenoma; one of the cancers diagnosed at age <45 years and the adenoma diagnosed at age <40 years.

4. Subjects with CRC or endometrial cancer diagnosed at age <45 years.

5. Subjects with right-sided CRC with an undifferentiated pattern (solid/cribiform) on histopathology diagnosed at age <45 years.

6. Subjects with signet ring cell type CRC diagnosed at age <45 years.

7. Subjects with adenomas diagnosed at age <40 years.