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Table 4 Statistical analysis of nuclear pedigree clinical features of CRC patients with identified mutations

From: Nuclear Pedigree Criteria of Suspected HNPCC

Criterion No. of HNPCC cases No. of consecutive cases OR CI sensitivity specificity p
Total 43 % 629 %   from to % %  
F1 39 90.70 100 15.90 51.6 18.03 147.5 90.70 84.10 0.0000
F2 5 11.63 54 8.59 1.4 0.53 37.1 11.63 91.41 0.4970
F3 41 95.35 102 16.22 105.9 25.22 444.8 95.35 83.78 0.0000
F4 26 60.47 24 3.82 38.5 18.5 80.4 60.47 96.18 0.0000
F5 30 69.77 43 6.84 31.4 15.3 64.65 69.77 93.16 0.0000
F1 without (F3 or/and F5)* 1 2.33 81 12.88 0.16 0.02 1.19 2.33 87.12 0.0408
F1 and (F3 or/and F5)** 39 90.70 51 8.16 110.5 39.4 307.9 90.70 91.84 0.0000
F4 without F1 and without F2*** 2 4.65 18 2.86 1.66 0.37 7.38 1.09 97.13 0.5041
  1. * HNPCC closely associated cancer in first degree relative of CRC patient; none of these cancers were diagnosed under the age of 50.
  2. ** HNPCC closely associated cancer in first degree relative of CRC patient; at least one of cancers was diagnosed under the age of 50.
  3. *** sporadic CRC diagnosed under the age of 40.