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Table 4 Statistical analysis of nuclear pedigree clinical features of CRC patients with identified mutations

From: Nuclear Pedigree Criteria of Suspected HNPCC

Criterion

No. of HNPCC cases

No. of consecutive cases

OR

CI

sensitivity

specificity

p

Total

43

%

629

%

 

from

to

%

%

 

F1

39

90.70

100

15.90

51.6

18.03

147.5

90.70

84.10

0.0000

F2

5

11.63

54

8.59

1.4

0.53

37.1

11.63

91.41

0.4970

F3

41

95.35

102

16.22

105.9

25.22

444.8

95.35

83.78

0.0000

F4

26

60.47

24

3.82

38.5

18.5

80.4

60.47

96.18

0.0000

F5

30

69.77

43

6.84

31.4

15.3

64.65

69.77

93.16

0.0000

F1 without (F3 or/and F5)*

1

2.33

81

12.88

0.16

0.02

1.19

2.33

87.12

0.0408

F1 and (F3 or/and F5)**

39

90.70

51

8.16

110.5

39.4

307.9

90.70

91.84

0.0000

F4 without F1 and without F2***

2

4.65

18

2.86

1.66

0.37

7.38

1.09

97.13

0.5041

  1. * HNPCC closely associated cancer in first degree relative of CRC patient; none of these cancers were diagnosed under the age of 50.
  2. ** HNPCC closely associated cancer in first degree relative of CRC patient; at least one of cancers was diagnosed under the age of 50.
  3. *** sporadic CRC diagnosed under the age of 40.
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287