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Table 3 Statistical analysis of nuclear pedigree clinical features of CRC patients from HNPCC families in total

From: Nuclear Pedigree Criteria of Suspected HNPCC

Criterium No. of HNPCC cases No. of consecutive cases OR CI sensitivity specificity p
Total 182 % 629 %   from to % %  
F1 176 96.70 100 15.90 155.2 66.9 359.9 96.70 84.10 0.0000
F2 7 3.85 55 8.74 0.42 0.19 0.9 3.85 91.26 0.0490
F3 142 78.02 102 16.22 18.3 12.2 27.6 78.02 83.78 0.0000
F4 70 38.46 24 3.82 15.8 9.5 26.1 38.46 96.18 0.0000
F5 134 73.63 43 6.84 38 24.2 59.8 73.63 93.16 0.0000
F1 without (F3 or/and F5)* 6 3.30 80 12.7 0.23 0.10 0.55 3.30 87.3 0.0003
F1 and (F3 or/and F5)** 170 93.41 51 8.16 160.6 84.2 305.5 93.41 91.84 0.0000
F4 without F1 and without F2*** 2 1.10 38 6.04 0.17 0.04 0.72 1.10 93.96 0.0160
  1. * HNPCC closely associated cancer in first degree relative of CRC patient; none of these cancers were diagnosed under the age of 50.
  2. ** HNPCC closely associated cancer in first degree relative of CRC patient; at least one of cancers was diagnosed under the age of 50.
  3. *** sporadic CRC diagnosed under the age of 40.