Nuclear Pedigree Criteria of Suspected HNPCC

Table 3 Statistical analysis of nuclear pedigree clinical features of CRC patients from HNPCC families in total

Criterium	No. of HNPCC cases		No. of consecutive cases		OR	CI		sensitivity	specificity	p
Total	182	%	629	%		from	to	%	%
F1	176	96.70	100	15.90	155.2	66.9	359.9	96.70	84.10	0.0000
F2	7	3.85	55	8.74	0.42	0.19	0.9	3.85	91.26	0.0490
F3	142	78.02	102	16.22	18.3	12.2	27.6	78.02	83.78	0.0000
F4	70	38.46	24	3.82	15.8	9.5	26.1	38.46	96.18	0.0000
F5	134	73.63	43	6.84	38	24.2	59.8	73.63	93.16	0.0000
F1 without (F3 or/and F5)*	6	3.30	80	12.7	0.23	0.10	0.55	3.30	87.3	0.0003
F1 and (F3 or/and F5)**	170	93.41	51	8.16	160.6	84.2	305.5	93.41	91.84	0.0000
F4 without F1 and without F2***	2	1.10	38	6.04	0.17	0.04	0.72	1.10	93.96	0.0160

* HNPCC closely associated cancer in first degree relative of CRC patient; none of these cancers were diagnosed under the age of 50.
** HNPCC closely associated cancer in first degree relative of CRC patient; at least one of cancers was diagnosed under the age of 50.
*** sporadic CRC diagnosed under the age of 40.

ISSN: 1897-4287