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Table 2 Definition of analysed pedigree/clinical features

From: Nuclear Pedigree Criteria of Suspected HNPCC

Feature No Definition
F1 at least one first degree relative of the index patient with CRC affected by an HNPCC closely associated cancer*
F2 at least one other malignancy associated with HNPCC (cancers of the stomach, hepatobiliary tract, ovary, pancreas or gliomas) in a first degree relative of patient with CRC
F3 CRC diagnosed under the age of 50
F4 CRC diagnosed under the age of 40
F5 HNPCC closely associated cancer* diagnosed under the age of 50 in first degree relatives of an index patient with CRC
  1. * of the colon, rectum, endometrium, small bowel, urinary tract.