One colorectal cancer patient with at least one of the following: |
Presence of synchronous or metachronous colorectal tumors in the patient, one of which occurred under the age of 40 years. |
Endometrial, urinary tract, or small-intestinal cancer in the patient or a first degree relative (one aged <50 years). |
At least two first degree relatives (one aged <50 years) with other extra-colonic cancers (stomach, hepatobiliary system, ovary, or brain). |