Fig. 2
From: Synchronous choroid plexus papilloma and Wilms tumor in a girl, disclosing a Li-Fraumeni syndrome
Findings from the molecular genetic analysis of TP53 gene in patient’s tissues. Sanger sequencing. From top to bottom traces show wild-type control DNA, patient’s CPP DNA, Wilms tumor DNA, both carrying the pathogenic TP53 mutation in homozygous status consistent with the absence of the wild type allele, and in the lower trace the heterozygous germline TP53 mutation. The TP53 missense mutation in exon 8 (c.844C > T; p.R282W; CGG > TGG) is marked in yellow