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Table 1 Frequency of polymorphisms rs3803662 (TNRC9), rs2981582 (FGFR2), rs13281615, rs889312 (MAP3K1) and rs3817198 (LSP1) per group

From: Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes

Variable

Group 1

Group 2

Group 3

P valuea

N (%)

N (%)

N (%)

rs3803662 (TNRC9)

   

0.027

 TT

5 (9.8)

12 (22.6)

17 (17.3)

 CT

27 (52.9)

24 (45.3)

47 (48.0)

 CC

19 (37.3)

17 (32.1)

34 (34.7)

rs2981582 (FGFR2)

   

0.031

 TT

14 (27.5)

9 (16.7)

26 (26.3)

 CT

22 (43.1)

33 (61.1)

49 (49.5)

 CC

15 (29.4)

12 (22.2)

24 (24.2)

rs13281615 (8q24)

   

0.029

 AA

14 (27.5)

11 (20.4)

27 (27.0)

 AG

24 (47.1)

26 (48.1)

48 (48.0)

 GG

13 (25.5)

17 (31.5)

25 (25.0)

rs889312 (MAP3K1)

   

0.029

 CC

8 (15.7)

8 (14.8)

11 (11.0)

 CA

21 (41.2)

20 (37.0)

55 (55.0)

 AA

22 (43.1)

26 (48.1)

34 (34.0)

rs3817198 (LSP1)

   

0.023

 TT

26 (51.0)

28 (51.9)

44 (44.4)

 TC

22 (43.1)

24 (44.4)

43 (43.4)

 CC

3 (5.9)

2 (3.7)

12 (12.1)

  1. Group 1: women with germline mutations in the BRCA1/BRCA2 genes; Group 2: women with VUS in the BRCA1/BRCA2 genes; Group 3: women WT for the BRCA1/BRCA2 genes; Group 4: control, sporadic group
  2. Values in bold indicate statistical significance (p < 0.05)
  3. aChi-square