Gene / SNP | Breast cancer risk | BCAC manuscript |
---|---|---|
CASP8 D302H | CG v. GG: OR 0.89, 95% CI 0.85-0.94 CC v. GT: OR 0.74, 95% CI 0.62-0.87 | Cox et al., Nat Genet 2007 |
FGFR2, rs2981582 TNRC9, rs3803662 MAP3K1, rs889312 LSP, rs3817198 8q24, rs13281615 | ORhom 1.63, 95% CI 1.53-1.72, p=4.1 × 10-76 ORhom 1.39, 95% CI 1.25-1.45, p=1.4 × 10-36 ORhom 1.27, 95% CI 1.19-1.36, p=4.1 × 10-20 ORhom 1.17, 95% CI 1.08-1.25, p=4.1 × 10-9 ORhom 1.18, 95% CI 1.10-1.25, p=4.1 × 10-12 | Easton et al., Nat Genet 2007 |
FGFR2, 2981582 8q24, 13281615 TNRC9, rs3803662 | ER positive:p=10-13 PGR positive: p=10-5 low grade: p=10-8 metastases: p=0.013 ER positive: p=0.001 PGR positive: p=0.011 low grade: p=10-4 ER negative: OR 1.14, 95% CI 1.09-1.21 | Garcia-Closas et al., PLoS Genet 2008 |
AKAP9 M463I | TT v. GG: OR 1.17, 95% CI 1.08-1.27, p=0.0003 familial cases: OR 1.27, 95% CI 1.12-1.45, p=0.0003 TT v. GT: OR 1.10, 95% CI 1.04-1.17, p=0.001 familial cases: OR 1.16, 95% CI 1.06-1.27, p=0.001 | Frank et al., JNCI 2008 |
3p24, rs4973768 17q23, rs6504950 | ORper-allele 1.11, 95% CI 1.08-1.13, p=4.1 × 10-23 ORper-allele 0.95, 95% CI 0.92-0.97, p=1.4 × 10-8 | Ahmed et al., Nat Genet 2009 |
2q35, rs13387042 | OR per-allele 1.12, 95% CI 1.09 -1.15; ptrend 1.0 × 10-19 (European Caucasian) ER positive: OR 1.14, 95% CI 1.10-1.17; p=10-15 ER negative: OR 1.10, 95% CI 1.04-1.15; p=0.0003 PGR positive: OR 1.15, 95% CI 1.11-1.19; p=5 × 10-14 PGR negative: OR 1.10, 95% CI 1.06-1.15; p=0.00002 | Milane et al., JNCI 2009 |