Mutation positive family members: Family number - Cancer history (Age of diagnosis or age at last follow up) | Gender | Other family cancers (Age and relationship to proband) - mutation status unknown | Fulfilled Am II criteria |
---|---|---|---|
MSH6_1- CRC (31) MSH6_1.1- no cancer (69) MSH6_1.2- no cancer (33) | F F M | 1 Endometrial (63-mother), 1 CRC + Oesophagus (mothers brother), 1 Ovarian (mothers sister), 1 Throat (mothers brother), 1 Stomach (mothers father), 1 CRC (grand fathers sister) | Yes |
MSH6_2- CRC (64) MSH6_2.1- no cancer (76) | M M | 1 CRC + Pancreatic (50 + 84 - mother), 1 Prostate (70-brother) | Yes |
MSH6_3- CRC (50) | F | 1 CRC × 2 (64 + 71 - mother), 1 CRC & Prostate (60s - mothers 1st cousin) | Yes |
MSH6_4- CRC(72), Endometrial (74) MSH6_4.1- CRC (37) daughter of proband MSH6_4.2- no cancer (55) MSH6_4.3- no cancer (18) | F F M F | 1 CRC (70-brother), 1 Pituitary tumour (15-brothers granddaughter), 1 Breast (60s-sister who has 1 daughter with Breast and Uterine cancer (52) and 1 daughter with Brain & Lung cancer (< 64) No cancer in parents of proband - father d.76, mother died when proband was 6 months old | Yes |
MSH6_5- CRC (58) | F | 1 CRC (63-mother), 3 CRC (67+78+55 - maternal half siblings), 1 Endometrial (67-maternal half sister), 1 Liver (32-maternal half brother), 2 CRC (40+53-half brothers children) | Yes |
MSH6_6 - no information available MSH6_6.1- no information available MSH6_6.2- no information available | F F F | No pedigree available | Unknown |
MSH6_7- CRC (41) | M | 1 Hodgkins Lymphoma (13-niese), 1 Bladder (fathers sister who has 2 daughters with Cervical cancer and a grandson with Lung cancer (19), 1 Prostate (fathers brother), 1 Breast (40s-fathers sister), 1 CRC (70s-grandfather who has 2 brothers with cancer of Unknown origin). No cancer in parents of proband - age 65 + 67. | Yes |
MSH6_8- CRC (?) MSH6_8.1- Ovarian (49) MSH6_8.2- no cancer (59) MSH6_8.3- no cancer (29) MSH6_8.4- Appendix (14) | M F F M F | No pedigree available | Unknown |
MSH6_9- Bladder (69), Endometrial (71), Thyroid (72) | F | 1 Lymphoma (77-brother), 1 CRC + Prostate (81 + 75 - brother), 1 Unknown (42 - son) No cancer in parents of proband - mother d.77, father d.73 | Yes |
MSH6_10- CRC (21), Non-Hodgkin Lymphoma (6) MSH6_10.1- Endometrial (68), paternal grandmother MSH6_10.2- Non Hodgkin Lymphoma (28), paternal aunty MSH6_10.3- no cancer (65) | F F F F | 1 CRC (70s-grandmothers uncle), 1 Breast (60-grandmothers uncle who has 1 daughter with Ovarian cancer but who is mutation negative), 1 CRC (41-grandmothers sister's son who is also mutation negative), 2 Breast cancer (53+? - grandmothers sister and grandmothers aunt, both are mutation negative) | Yes |
MSH6_11- CRC (40) MSH6_11.1- no cancer (64) MSH6_11.2- no cancer (38) MSH6_11.3- no cancer (39) MSH6_11.4- no cancer (31) | M M F F F | 1 CRC (63-sister), 1 Prostate (56-brother), 1 Throat (maternal grandfather) No cancer in parents - mother d.60s, dad d.70s | No |
MSH6_12- no cancer (44) | M | 3 Endometrial (mother and maternal aunt and grandmother), 2 Unknown (brothers - one of which is the proband somewhere else), 1 Unknown (maternal uncle) | No/Bethesda |
MSH6_13- Endometrial (54) MSH6_13.1- no cancer (60) MSH6_13.2- no cancer (57) MSH6_13.3- no cancer (37) MSH6_13.4- no cancer (55) MSH6_13.5- no cancer (37) MSH6_13.6- no cancer (34) MSH6_13.7- Endometrial (56), sister | F F M F M F F F | 1 CRC + Uterine (60s-mother) | Yes |
MSH6_14- no cancer (48) | M | 1 CRC + Prostate (64-father), 1 Endometrial (55-fathers sister), 1 CRC (62-paternal grandmother) | No |
MSH6_15- CRC (54) MSH6_15.1- no cancer (43) MSH6_15.2- no cancer (67) MSH6_15.3- no cancer (31) MSH6_15.4- no cancer (70) | F F F F M | 1 CRC & Ovary (47+60s - mother), 1 Endometrial/Ovarian (sister), 6 CRC (maternal uncles), 5 CRC (maternal 1st cousins), 1 Leukaemia (maternal 1st cousin), 1 Ovarian (maternal 1st cousin) | Yes |
MSH6_16- Endometrial (50), Breast (63) MSH6_16.1- Endometrial (57), Breast (61), sister | F F | 1 Breast (82-mother), 1 Breast (56-1st cousin), 1 Breast (40s-mothers 1st cousin) | No |
MSH6_17- no cancer (42) | F | 1 Endometrial (41-sister), 1 Cervix (22-sister), 1 CRC (60s-father), 1 CRC + Bladder (mothers brother), 1 Breast (52-paternal grandmother), 1 Throat (79-paternal grandfather, smoker) | Yes |
MSH6_18- CRC (43) MSH6_18.1- no cancer (23) MSH6_18.2- no cancer (20) MSH6_18.3- no cancer (55) MSH6_18.4- Endometrial (44), sister | F M F M F | 1 Lung (d.53-father), 1 Hodgkins Lymphoma (21-niese) | No/Bethesda |
MSH6_19- CRC (46+67) | M | 1 Endometrial (49-mother), 1 Thyroid (44-daughter), 2 Unknown (mothers sisters) | Yes |
MSH6_20- CRC (48) MSH6_20.1- no cancer 26) MSH6_20.2- no cancer (53) | F M F | 1 Endometrial + CRC (54+70 - mother,1 Stomach (40s-maternal grandfather) | Yes |
MSH6_21- CRC (31) MSH6_21.1- no cancer (49) MSH6_21.2- no cancer (28) MSH6_21.3- no cancer (55) MSH6_21.4- CRC (58), aunty MSH6_21.5- no cancer (37) MSH6_21.6- no cancer (60) MSH6_21.7- no cancer (38) MSH6_21.8- no cancer (29) MSH6_21.9- no cancer (33) | M F M F F F F M F F | 2 CRC (39+42 - maternal uncles), 1 Lung (d.69-dad, smoker) Mother is mutation positive but with no cancer | Yes |
MSH6_22- CRC (54) MSH6_22.1- no cancer (45) | M F | 1 CRC (48-father), 1 Ovarian (51-fathers sister), 1 CRC (34-fathers brother who has 1 daughter with CRC (52), 1 CRC (62-fathers brother uncle), 1 Breast (67-fathers sister) | Yes |
MSH6_23- Endometrial (64), Breast (70) | F | No pedigree available | Unknown |
MSH6_24- CRC (50) | F | 1 Renal (father), 1 Endometrial (fathers sister), 1 Gallbladder (fathers sister), 1 Stomach (dx 56 - grandfather) | Yes |
MSH6_25- CRC (63) | F | 1 Unknown (maternal grandfather) No cancer in parents of proband - father d.60s, mother d.80s | No |
MSH6_26- CRC (66+67) MSH6_26.1- Bladder (52), brother MSH6_26.2- no cancer (68) | M M M F | 2 CRC (59+59 - brothers), 1 Melanoma (brother) No cancer in parents of proband - both d.80s | No |
MSH6_27- CRC (38) | M | No family history of cancer | No |
MSH6_28- Endometrial (50) | F | 1 Uterine (50s - mother), 1 Unknown (mothers sister), 1 Uterus (52 - maternal grandmother), 1 ALL (son), 1 Leukaemia (82 - father), 1 Prostate (paternal grandfather) | Unknown |
MSH6_29- Ovarian (38) | F | No pedigree available | Unknown |