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Figure 1 | Hereditary Cancer in Clinical Practice

Figure 1

From: Large family with both parents affected by distinct BRCA1 mutations: implications for genetic testing

Figure 1

Pedigree of the breast-ovarian cancer family with 2 BRCA1 mutations. Circles and squares indicate females and males, respectively. Crossed symbols are used for deceased subjects; age at death is given after the letter "d", otherwise current age is provided. Black circles correspond to females affected by breast or ovarian cancer; half-filled circles are used for yet healthy BRCA1 mutation carriers; gray symbols depict subjects with unknown or non-breast-ovarian tumors. BC – breast cancer; OC – ovarian cancer; age at cancer diagnosis is given in brackets. All tested subjects carried either BRCA1 5382insC or BRCA1 1629delC allele, i.e. missing information on the BRCA1 status indicates that DNA from this family member has not been analyzed. Index cases are designated by arrows (see the text).

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287