Table 2 Estimates of cumulative risks (%) to ages 30, 50, and 70 (and corresponding 95% confidence intervals) for colorectal cancer stratified by MMR mutation status and gender using Kaplan-Meier analysis
Mutation | Gender | Age 30 | Age 50 | Age 70 |
|---|---|---|---|---|
Carrier of any MMR mutation Carrier | Male (n = 27) | - | 21 (0, 39) | 67 (3, 89) |
Female (n = 33) | 4 (0, 10) | 35 (6, 55) | 51 (16, 71) | |
Combined (n = 60) | 2 (0, 6) | 29 (10, 44) | 55 (28, 72) | |
MLH1 carrier | Male (n = 13) | - | 40 (0, 70) | 70 (0, 94) |
Female (n = 12) | - | - | 38 (0, 68) | |
Combined (n = 25) | - | 16 (0, 34) | 50 (4, 73) | |
MSH2 carrier | Male (n = 12) | - | - | - |
Female (n = 23) | 5 (0, 15) | 61 (9, 83) | 61 (9, 83) | |
Combined (n = 35) | 3 (0, 10) | 36 (6, 56) | 56 (15, 77) | |
Non-carrier of all mutations | Male (n = 22) | - | - | - |
Female (n = 40) | - | 7 (0, 19) | 7 (0, 19) | |
Combined (n = 62) | - | 4 (0, 11) | 4 (0, 11) | |
Any mutation unknown | Male (n = 195) | 2 (0, 5) | 23 (14, 31) | 46 (34, 57) |
Female (n = 157) | 4 (0, 7) | 13 (6, 20) | 41 (27, 52) | |
Combined (n = 352) | 3 (1, 5) | 19 (13, 24) | 44 (35, 52) |