Table 5 Comparison of CDKN2A-positive and CDKN2A-negative breast cancer cases
Parameters | Â | p16-positive | p16-negative | p |
|---|---|---|---|---|
| Â | Â | n = 157 | n = 2912 | Â |
age (mean) | Â | 44.35 | 44.34 | 0.9 |
age group | 20–30 | 6/157 (3.82%) | 51/2912 (1.75%) | 0.11 |
|  | 31–40 | 21/157 (13.38%) | 501/2912 (17.2%) | 0.25 |
|  | 41–50 | 130/157 (82.80%) | 2360/2912 (81.04%) | 0.66 |
histology | "low grade" | 32/108 (29.63%) | 637/2012 (31.66%) | 0.74 |
| Â | "high grade" | 15/108 (13.88%) | 303/2012 (15.06%) | 0.85 |
| Â | medullary | 6/108 (5.55%) | 112/2012 (5.57%) | 0.99 |
| Â | lobular | 18/108 (16.66%) | 388/2012 (19.28) | 0.58 |
| Â | tubulo-lobular | 6/108 (5.55%) | 89/2012 (4.42%) | 0.75 |
| Â | DCIS | 16/108 (14.81%) | 170/2012 (8.45%) | 0.04 |
| Â | other | 15/108 (13.88%) | 313/2012 (15.56%) | 0.74 |
| Â | no data or unknown | 12/108 (11.11%) | 225/2012 (11.18%) | 0.89 |
pre-operative | positive | 37/151 (24.5%) | 675/2012 (24.5%) | 0.99 |
chemotherapy | Â | Â | Â | Â |
ER | positive | 61/91 (67.03%) | 1085/1698 (63.9%) | 0.58 |
tumour size | <1 cm | 9/99 (9.09%) | 185/1767 (10.47%) | 0.87 |
|  | 1–1.9 cm | 43/99 (43.43%) | 798/1767 (45.16%) | 0.76 |
|  | 2–4.9 cm | 46/99 (46.46%) | 742/1767 (42%) | 0.72 |
| Â | >5 cm | 1/99 (1.01%) | 42/1767 (2.38%) | 0.73 |
nodal status | positive | 37/100 (37%) | 752/1801 (41.75%) | 0.4 |
multi-centricity | present | 18/90 (20%) | 340/1898 (17.91%) | 0.58 |
laterality | present | 5/138 (3.62%) | 88/2573 (3.42%) | 0.96 |
family history | positive (+) | 11/146 (7.5%) | 240/2658 (9%) | 0.64 |