Table 1 Genes with brain-related function or expression that were significantly altered in association with neurological symptoms in XP
Acc. No. | Name | Function | P value |
|---|---|---|---|
AA464744 | KIAA1111 | brain cDNA clone | 0.00004 |
R79082 | protein tyrosine phosphatase | cellular signalling pathways | 0.0004 |
N35888 | phosphomannomutase 2 (PMM2) | brain specific glycosylation factor | 0.0007 |
R93912 | glycogen synthase kinase 3 beta (GSK3 beta) | signal cascade of neuronal apoptosis | 0.0008 |
N70841 | GABA-B Receptor 1a | neurotransmitter receptor | 0.0008 |
T64482 | esterase D/formylglutathione hydrolase | expressed predominantly in brain | 0.0008 |
AA463251 | nucleosome assembly protein (NAP) | induces neuronal apoptosis | 0.0008 |
AA495858 | hydroxymethylbilane synthase | cell cycle and differentiation in glioma cells | 0.0023 |
AA460927 | translin | dendritic RNA binding comlex | 0.0034 |
N33331 | peroxisome proliferator activated receptor (PPAR) | anti-inflammatory and decreases free radical formation | 0.0062 |
AA456830 | diacylglycerol kinase (DAGK) | myelination | 0.0064 |
AA504333 | endothelial-monocyte activating polypeptide II (EMAPII) | brain inflammatory response | 0.0069 |
AA644088 | cathepsin C | upregulated after brain ischaemia | 0.0071 |
H19522 | exostoses-like protein 1 (EXTL1) | tumour suppressor, highly expressed in brain | 0.0076 |
| Â | transducer of erbB2 (Tob) | tumour suppressor, highly expressed in brain | 0.0076 |
AA489331 | adenosine deaminase | metabolism of adenosine | 0.0083 |