Hereditary Colorectal Cancer in China

Table 1 Comparison of clinical diagnostic criteria for HNPCC

Criteria Items colorectal cancer patients	Amsterdam criteria (including I and II) ≥3 (including extracolonic tumours)	Japanese criteria A ≥3	Chinese criteria ≥2	Japanese criteria B ≥2	Bethesda guidelines (2004) ≥1
first-degree relatives	at least 2 pairs	at least 2 pairs	at least 1 pair	at least 1 pair	no request
generations affected	at least 2 successive generations	no request	no request	no request	no request
exclude FAP	yes	no request	no request	no request	no request
with any of these:	at least 1 should be diagnosed before age 50	no request	at least 1 should be diagnosed before age 50	at least 1 should be diagnosed before age 50	CRC diagnosed before age 50
			multiple colorectal tumors (including adenomas)	multiple colorectal cancers	Multiple colorectal tumors
			extracolorectal cancer	extracolorectal cancer	HNPCC-associated tumours
				right colon involvement	MSI-H pathologic associated features in a colorectal cancer diagnosed before age 60
					- one with colorectal cancer - one or more first - or second-degree relatives with HNPCC-related tumour - one of the cancers being diagnosed before age 50
					- one with colorectal cancer - two or more first - or second-degree relatives with HNPCC-related tumour

Note: MSI-H pathologic associated features including the presence of tumor infiltrating lymphocytes, Crohn's-like lymphocytic reaction, mucinous/signet-ring differentiation, or medullary growth pattern

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