Syndrome | Histological type of renal cancer | Gene | Mode of inheritance | Frequency of syndromes | References |
---|---|---|---|---|---|
A. VHL | Clear cell carcinoma | VHL | AD | 1:36000 | |
B. Hereditary clear cell carcinoma | Clear cell carcinoma | FHIT? | AD | 4 families reported | |
TRC? | |||||
Papillary carcinoma | MET | AD | ? | ||
C. Lynch (HNPCC) | Urothelial carcinoma | hMSH2 | AD | 1:2000 | |
hMLH1 | |||||
D. Tuberous sclerosis | Clear cell carcinoma | TSC1 | AD | ? | |
Papillary carcinoma | TSC2 | ||||
E. Bean | ? | ? | AD | simple families | [36] |
F. Cowden | ? | PTEN | AD | ? | [37] |
G. Gorlin | ? | PTCH | AD | ? | [38] |
H. Fanconi anaemia | ? | FANCA | AR | ? | |
FANCC | |||||
FANCD | |||||
FANCG | |||||
FANCE | |||||
I. MEN1 | Oncocytoma | MEN1 | AD | ? | |
J. Reed | ? | ? | AD | simple families | [45] |
K. Werner | ? | WRN | AR | simple families | |
L. Birt-Hogg-Dube | ? | ? | AD | simple families | [50] |
M. Syndrome of multiple adenomas and carcinoma of large bowel | ? | CRAC1 | AD | one family | [51] |
N. 'Diffuse tubulocystic renal hyperplasia with renal cell carcinoma' | Tubulo-papillary carcinoma | ? | de novo | two cases | [52] |