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Volume 13 Supplement 2

Meeting abstracts from the Annual Conference on Hereditary Cancers 2014

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Pathological complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients

Hereditary Cancer in Clinical Practice volume 13, Article number: A8 (2015) Cite this article

Purpose

To estimate the frequency of pathologic complete response (pCR) after neoadjuvant treatment with cisplatin chemotherapy in women with breast cancer and who are BRCA1 mutation carriers.

Patients and Methods

107 women with BRCA1 mutation and affected with breast cancer, who presented with stage I to III breast cancer between December 2006 and June 2014 received treatment with cisplatin 75 mg/m2 every three weeks for four cycles, followed by mastectomy and conventional chemotherapy (AC). Information on clinical stage, grade, hormone receptor status and HER2 status was collected prior to treatment. Review of surgical samples was done in order to determine the pathologic complete response.

Results

107 patients were included in the study. 93 patients were treated for first primary breast cancer and 14 patients had previously received treatment for a prior cancer. A pathologic complete response was observed in 65 of the 107 patients (61%).

Conclusions

In a high proportion of patients with BRCA1-associated breast cancer platinum-based chemotherapy is an effective method of treatment.

Author information

Authors and Affiliations

  1. Department of Oncology, Pomeranian Medical University. International Hereditary Cancer Center, Szczecin, Poland

    Tomasz Byrski

  2. Department of Genetics and Pathology, Pomeranian Medical University. International Hereditary Cancer Center, Szczecin, Poland

    Tomasz Huzarski, Jacek Gronwald, Cezary Cybulski & Jan Lubinski

  3. Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada

    Rebecca Dent

  4. Oncology Institute, Krakow, Poland

    Elzbieta Marczyk, Marek Jasiowka & Jerzy Jakubowicz

  5. Regional Oncology Center, Bielsko-Biala, Poland

    Rafal Wisniowski

  6. Center for Epidemiology and Prevention, Poznan, Poland

    Dariusz Godlewski

  7. Women's College Research Institute, Toronto, Ontario, Canada

    Steven A Narod

Authors
  1. Tomasz Byrski
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  2. Tomasz Huzarski
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  3. Rebecca Dent
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  4. Elzbieta Marczyk
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  5. Marek Jasiowka
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  6. Jacek Gronwald
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  7. Jerzy Jakubowicz
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  8. Cezary Cybulski
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  9. Rafal Wisniowski
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  10. Dariusz Godlewski
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  11. Jan Lubinski
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  12. Steven A Narod
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Byrski, T., Huzarski, T., Dent, R. et al. Pathological complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Hered Cancer Clin Pract 13 (Suppl 2), A8 (2015). https://doi.org/10.1186/1897-4287-13-S2-A8

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  • DOI: https://doi.org/10.1186/1897-4287-13-S2-A8

Keywords

Hereditary Cancer in Clinical Practice

ISSN: 1897-4287