Criteria Items colorectal cancer patients | Amsterdam criteria (including I and II) ≥3 (including extracolonic tumours) | Japanese criteria A ≥3 | Chinese criteria ≥2 | Japanese criteria B ≥2 | Bethesda guidelines (2004) ≥1 |
---|---|---|---|---|---|
first-degree relatives | at least 2 pairs | at least 2 pairs | at least 1 pair | at least 1 pair | no request |
generations affected | at least 2 successive generations | no request | no request | no request | no request |
exclude FAP | yes | no request | no request | no request | no request |
with any of these: | at least 1 should be diagnosed before age 50 | no request | at least 1 should be diagnosed before age 50 | at least 1 should be diagnosed before age 50 | CRC diagnosed before age 50 |
 |  |  | multiple colorectal tumors (including adenomas) | multiple colorectal cancers | Multiple colorectal tumors |
 |  |  | extracolorectal cancer | extracolorectal cancer | HNPCC-associated tumours |
 |  |  |  | right colon involvement | MSI-H pathologic associated features in a colorectal cancer diagnosed before age 60 |
 |  |  |  |  | - one with colorectal cancer - one or more first - or second-degree relatives with HNPCC-related tumour - one of the cancers being diagnosed before age 50 |
 |  |  |  |  | - one with colorectal cancer - two or more first - or second-degree relatives with HNPCC-related tumour |